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KMID : 0614620110580020074
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Korean Journal of Gastroenterology
2011 Volume.58 No. 2 p.74 ~ p.81
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Primary Antibiotic Resistance of Helicobacter pylori Strains and Eradication Rate according to Gastroduodenal Disease in Korea
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Kim Jae-Yeon
Kim Na-Young
Park Hyun-Kyung
Jo Hyun-Jin
Shin Cheol-Min
Lee Sang-Hyub
Park Young-Soo
Hwang Jin-Hyeok
Kim Jin-Wook
Jeong Sook-Hyang
Lee Dong-Ho
Nam Ryoung-Hee
Kim Jung-Mogg
Lee Ji-Hyun
Jung Hyun-Chae
Song In-Sung
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Abstract
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Background/Aims : This study was performed to evaluate whether the prevalence rates of primary antibiotic resistance in Helicobacter pylori (H. pylori) isolates and the eradication rate of H. pylori could be different between cancer and non-cancer patients.
Methods: H. pylori were isolated from gastric mucosal biopsy specimens obtained from 269 Koreans, who did not have any eradication therapy history and were diagnosed as one of the following diseases; chronic gastritis, benign gastric ulcer, duodenal ulcer or gastric cancer. The susceptibilities of the H. pylori isolates to amoxicillin, clarithromycin, metronidazole, tetracycline, azithromycin, ciprofloxacin, levofloxacin and moxifloxacin were examined with the agar dilution method. In addition, eradication rate of H. pylori was evaluated.
Results: There was no significant difference in the primary antibiotic resistance to above eight antibiotics among chronic gastritis, peptic ulcer disease and gastric cancer. Furthermore there was no difference of antibiotic resistance between cancer and non-cancer patients, and there was no difference of eradication rate of H. pylori according to disease.
Conclusions:Primary antibiotic resistance and H. pylori eradication rate were not different between cancer and non-cancer patients.
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KEYWORD
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Helicobacter pylori, Antibiotic resistance, Cancer
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